Key result
Time-to-assay significantly influenced the platelet reactivity index, with PRI from mean fluorescence intensity lower after two days compared to day 1 (52 vs 57.7, p<0.001).
Observational (n=62)
Absolute Event Rate: 52% vs 57.7%
p-value: p=<0.001
Standardisation of the VASP-P assay is crucial, as the calculated platelet reactivity index depends significantly on the calculation method, time-to-assay, and lag time after processing, with median fluorescence intensity providing the most stable results.
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VASP-P timing variability may confound clinical interpretations; supports assay standardization in future platelet studies.
Bruno et al. (2012) conducted an observational in Patients on clopidogrel (n=62). Time-to-assay and lag time of processed samples vs. Baseline (Day 0 or Day 1) was evaluated on Platelet reactivity index (PRI) from mean fluorescence intensity (p=<0.001). Time-to-assay significantly influenced the platelet reactivity index, with PRI from mean fluorescence intensity lower after two days compared to day 1 (52 vs 57.7, p<0.001).
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