What question did this study set out to answer?

To assess the pre-analytical stability of blood samples analyzed by flow cytometry for VASP phosphorylation to measure clopidogrel response in coronary artery disease.

January 1, 2009Thrombosis and Haemostasis

High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease

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Key result

Blood samples for VASP flow cytometry show high stability for measuring clopidogrel responsiveness in CAD.

Why the study?

Does flow cytometric analysis of VASP phosphorylation provide high stability of blood samples for measuring clopidogrel responsiveness in patients with coronary artery disease?

Key Points

To assess the pre-analytical stability of blood samples analyzed by flow cytometry for VASP phosphorylation to measure clopidogrel response in coronary artery disease.
Obtained blood samples from patients diagnosed with coronary artery disease undergoing antiplatelet therapy with clopidogrel.
Measured vasodilator-stimulated phosphoprotein (VASP) phosphorylation via flow cytometry across storage intervals to test temporal stability.
Demonstrated robust stability of blood specimens over time for flow cytometric measurement of VASP phosphorylation.
Preserved assay accuracy across delayed testing intervals, supporting reliable post-collection evaluation of clopidogrel responsiveness.

Structured PICO

Does flow cytometric analysis of VASP phosphorylation provide high stability of blood samples for measuring clopidogrel responsiveness in patients with coronary artery disease?

Population

Patients with coronary artery disease

Intervention

Flow cytometric analysis of VASP phosphorylation to measure clopidogrel responsiveness

Outcome

Stability of blood samplessurrogate

Implication

Blood samples for flow cytometric analysis of VASP phosphorylation show high stability, supporting its use for measuring clopidogrel responsiveness in CAD patients.

Discussion

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Cite This Study

Christian Gachet (2009) studied this question. Blood samples for flow cytometric analysis of VASP phosphorylation demonstrate high stability for measuring clopidogrel responsiveness in patients with coronary artery disease.

synapsesocial.com/papers/6aacc3a970effab85c754736 https://doi.org/10.1160/th05-04-0886

Topics

Coronary artery disease

Dual antiplatelet therapy

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Implication

Blood samples for flow cytometric analysis of VASP phosphorylation show high stability, supporting its use for measuring clopidogrel responsiveness in CAD patients.

High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Topics

High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease

Key Points

Structured PICO

Implication

Discussion

Cite This Study

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