Why the study?
Does prophylactic lidocaine increase adverse effects compared to placebo in patients with proved or suspected myocardial infarction?
Population
285 patients arriving at the hospital within 6 hours of the onset of chest pain with proved or suspected…
Comparison
Prophylactic lidocaine therapy vs Placebo
Design
Cohort
Follow-up
48 hours
Authors
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Lidocaine was associated with more adverse effects than placebo; warrants caution and randomized trials to clarify net benefit in MI prophylaxis.
Does prophylactic lidocaine increase adverse effects compared to placebo in patients with proved or suspected myocardial infarction?
Prophylactic lidocaine for suspected myocardial infarction causes significantly more adverse effects than placebo, which may negate its antiarrhythmic efficacy.
Rademaker et al. (1986) studied this question.
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