What question did this study set out to answer?

To assess maternal-to-fetal transfer of IgG antibodies against human herpesvirus-6 and determine the age-specific prevalence of the virus in healthy individuals.

October 1, 1989PEDIATRICS

Distribution of Antibodies to a Causative Agent of Exanthem Subitum (Human Herpesvirus-6) in Healthy Individuals

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Authors

TYTetsushi YoshikawaFujita Health University SSSadao SugaTokyo Dental College Ichikawa General Hospital YAYoshizo AsanoFujita Health University

Discussion

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Implication

Cross-sectional serological analysis reveals maternal transfer and rapid infant acquisition of human herpesvirus-6 antibodies, highlighting widespread vulnerability between four and six months.

Key Points

To assess maternal-to-fetal transfer of IgG antibodies against human herpesvirus-6 and determine the age-specific prevalence of the virus in healthy individuals.
Measured maternal and cord blood IgG antibodies to human herpesvirus-6 in 20 mother-infant pairs using an indirect immunofluorescence assay.
Evaluated age-specific seroprevalence across 301 serum samples collected from healthy individuals ranging from birth through adulthood.
Maternal antibody seropositivity (>1:10) was 85% (17/20), whereas cord blood exhibited a 95% (19/20) positivity rate with a mean cord-to-maternal titer ratio of 1.63.
Infant antibody prevalence dropped from 87% in the first 2 months to a nadir of 6% at 4 to 5 months of age, then rose to 86% by 1 year of age.
Antibody seroprevalence stabilized between 69% and 76% from 2 years of age onward, matching levels observed in adolescents and adults.

Cite This Study

Yoshikawa et al. (1989) studied this question.

synapsesocial.com/papers/6a81b65be02763da79e03a8d https://doi.org/10.1542/peds.84.4.675

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Implication

Cross-sectional serological analysis reveals maternal transfer and rapid infant acquisition of human herpesvirus-6 antibodies, highlighting widespread vulnerability between four and six months.

Distribution of Antibodies to a Causative Agent of Exanthem Subitum (Human Herpesvirus-6) in Healthy Individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

Distribution of Antibodies to a Causative Agent of Exanthem Subitum (Human Herpesvirus-6) in Healthy Individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

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