Key result
Sensory neuropathy interferes with cardioprotective signalling in ischaemic heart disease, highlighting the need for therapeutic options targeting both conditions simultaneously.
Why the study?
Clinical translation of cardioprotection by ischaemic conditioning remains unmet, largely because comorbidities like sensory neuropathy interfere with cardioprotective signalling pathways.
Sensory neuropathy disrupts cardioprotective signaling, highlighting the need for therapeutic strategies that target both ischemic heart disease and sensory neuropathy simultaneously.
May inform risk stratification in comorbid neuropathy and IHD; leaves open dual-targeted therapies pending prospective trials.
During the last decades, mortality from acute myocardial infarction has been dramatically reduced. However, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischaemic conditioning had been discovered more than three decades ago. Its clinical translation, however, is still an unmet need. This is mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors, co-morbidities and the medication being taken. Sensory neuropathy is one of the co-morbidities that has been shown to interfere with cardioprotection. In the present review, we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which these neuropathies may interfere with ischaemic heart disease and cardioprotective signalling. Finally, we suggest future therapeutic options targeting both ischaemic heart and sensory neuropathy simultaneously. LINKED ARTICLES: This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.23/issuetoc.
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Bencsik et al. (2020) conducted a review in Myocardial ischaemia reperfusion injury and sensory neuropathy. Therapeutic options targeting ischaemic heart and sensory neuropathy was evaluated. Sensory neuropathy interferes with cardioprotective signalling in ischaemic heart disease, highlighting the need for therapeutic options targeting both conditions simultaneously.
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