Cardioprotection: emerging pharmacotherapy

Q: What does this research mean for the field?

Emerging pharmacotherapies targeting the fundamental mechanisms of ischaemia/reperfusion injury offer novel means to limit cardiomyocyte death and improve survival in acute coronary syndromes beyond early reperfusion. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Richard J. Gumina; Arshad Jahangir; Garrett J. Gross; André Terzic

doi:10.1517/14656566.2.5.739

May 1, 2001Expert Opinion on Pharmacotherapy

Cardioprotection: emerging pharmacotherapy

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Key Points

To review the fundamental cellular mechanisms of myocardial ischaemia/reperfusion injury and examine emerging cardioprotective pharmacotherapies designed to limit cardiomyocyte death.
Narrative review synthesizing mechanistic pathways of cardiomyocyte vulnerability during ischaemic insult and reperfusion injury.
Evaluation of available preclinical and clinical evidence for novel cardioprotective therapeutic candidates targeting acute coronary syndromes.
Cardiomyocyte susceptibility to lethal cell injury during ischaemia and subsequent reperfusion represents the primary physiological barrier to optimizing survival after acute coronary occlusion.
Novel pharmacological interventions targeted at delaying or limiting myocyte death show promise as adjunctive strategies to reperfusion therapy for improving myocardial salvage.

Structured PICO

P

Population

Patients with acute coronary syndromes and myocardial ischaemia

I

Intervention

Cardioprotective pharmacotherapy

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Implication

This review highlights emerging cardioprotective pharmacotherapies aimed at reducing ischaemia/reperfusion injury and improving myocardial salvage in acute coronary syndromes.

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Gumina et al. (2001) studied this question.

synapsesocial.com/papers/6a1a3288589f5a8c9bf6d23a https://doi.org/10.1517/14656566.2.5.739

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Cardioprotection: emerging pharmacotherapy

Key Points

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Cardioprotection: emerging pharmacotherapy

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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