Effects of varying degrees of renal impairment on the pharmacokinetic disposition of nebivolol

25 subjects, including 21 with varying degrees of renal impairment (mild n=7, moderate n=9, severe n=5) based on measured or calculated creatinine clearance, and 4 healthy control subjects matched for age, gender, weight, and smoking habit.

Nebivolol 5 mg oral

Healthy control subjects matched for age, gender, weight, and smoking habit

Pharmacokinetic disposition (AUC∞, apparent clearance Cl/F, Cmax, Tmax)surrogate