Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 2003Journal of Biological ChemistryOpen Access

Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes

View Full Paper
Ask AI
Bookmark
Share

Population

Human or mouse serum, adiponectin expressed in NIH-3T3 or Escherichia coli, and hepatocytes

Comparison

Human adiponectin mutations vs Wild-type adiponectin

Design

Preclinical

Authors

HWHironori WakiAkita UniversityTYToshimasa YamauchiBunkyo UniversityJKJunji KamonNissan (United Kingdom)

Discussion

Loading...

Member takes

Overview

Impaired adiponectin multimerization may underlie hypoadiponectinemia in diabetes; animal data leave open human validation and therapeutic relevance.

Structured PICO

P
Population
Human or mouse serum, adiponectin expressed in NIH-3T3 or Escherichia coli, and hepatocytes
I
Intervention
Human adiponectin mutations (G84R, G90S, R112C, I164T, and amino-terminal Cys-Ser mutation)
C
Comparator
Wild-type adiponectin
O
Outcome
Multimerization, cellular secretion, and effect on the AMP-activated protein kinase pathwaysurrogate

Adiponectin mutations associated with diabetes and hypoadiponectinemia cause impaired multimerization and/or secretion, highlighting the importance of multimer distribution in interpreting plasma adiponectin levels.

Cite This Study

Waki et al. (2003) studied this question.

synapsesocial.com/papers/6a81bcdc687698565bf20175https://doi.org/10.1074/jbc.m300365200
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduction of von Willebrand Factor by Endothelial Cells2000 · 35 citations
  2. 2Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation2002 · 1,216 citations
  3. 3Association of Adiponectin Mutation With Type 2 Diabetes2002 · 386 citations
  4. 4A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction.1990 · 152 citations
  5. 5Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation2001 · 218 citations