Population
Yeast strains (Saccharomyces cerevisiae and Schizosaccharomyces pombe)
Comparison
Deletion or mutation of the SLA1 gene vs Wild-type yeast cells
Design
Preclinical
Authors
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Yeast data implicate Sla1p in cell wall integrity; leaves open conservation and relevance in mammalian cytoskeletal disorders.
Sla1p is a modular component of the yeast cortical actin cytoskeleton essential for the proper localization of Sla2p and Rho1p, impacting cell wall biosynthesis.
Ayscough et al. (1999) studied this question.
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