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Hepatocellular carcinoma (HCC) is a hypervascular tumor characterized by neovascularization. Angiogenesis plays an important role in the growth and progression of HCC. Recent studies have indicated that assessment of angiogenic activity in HCC can provide prognostic information independent of conventional clinicopathological factors. Animal studies have demonstrated the efficacy of antiangiogenic agents in suppressing hepatocarcinogenesis and growth of HCC. Early clinical trials on the use of antiangiogenic agents in HCC have already been initiated. This article reviews the available literature on angiogenesis in HCC and discusses its potential clinical significance in the management of HCC. More: http://www.worldscientific.com/doi/abs/10.1142/S0219836303000256
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Ronnie Tung‐Ping Poon (2003) studied this question.
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