Population
Astronauts and subjects exposed to spaceflight or short- and long-term simulations of microgravity
Comparison
Exposure to spaceflight or microgravity… vs Preflight or baseline conditions
Design
Review
Authors
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May inform astronaut countermeasures for orthostatic intolerance; leaves open mechanisms and durability of biphasic sympathetic adaptation.
Sympathetic neural control is lowered during short-term microgravity but enhanced after long-term exposure, and a lack of enhanced sympathetic response to orthostatic stress may induce orthostatic intolerance.
Tadaaki Mano (2005) studied this question.
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