Answers are grounded in this paper and cite their sources.
A convergent synthesis of a pyrimidine core has been achieved. Treatment of alpha,alpha-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new method offers an easy access to functionalized pyrimidines.
No takes yet. Share an insight, caveat, or question.
Kakiya et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: