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SeqTrim is a pipeline designed to preprocessing sequence reads. It is easy to install and configure, flexible even if default parameters are accurate for most purposes and usable as a web interface or a standalone command line application. It identifies the sequence insert by removing low quality sequences, cloning vector, poly-A or poly-T tails, adaptors and any contaminant sequence or unwanted feature. Several input and output formats are available, which enables its inclusion in already or newly defined sequence processing work flows. It outperforms preprocessors implemented in other web servers and standalone applications at least in detecting adaptors and chimeric clones. SeqTrim is under continuous refinement to deal with most sequence events due to collaboration between biologists and computer scientists.
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Falgueras et al. (2010) studied this question.
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