Key result
Prior self-control exertion decreased pre-frontal cortex oxygenation but did not affect perceptions of dyspnoea or tolerance time during a CO2 rebreathing challenge (P>0.05).
Why the study?
Because state self-control can vary within individuals, researchers investigated whether prior self-control exertion influences dyspnoea perceptions and tolerance during a CO2 rebreathing challenge in healthy young males.
Does prior self-control exertion affect perceptions of dyspnoea and tolerance time during a CO2 rebreathing challenge in healthy young males?
Does prior self-control exertion affect perceptions of dyspnoea and tolerance time during a CO2 rebreathing challenge in healthy young males?
p-value: p=>0.05
Prior self-control exertion alters pre-frontal cortex oxygenation but does not impact dyspnoea perception or tolerance during a CO2 rebreathing challenge in healthy young males.
Self-control exertion does not affect dyspnoea tolerance in healthy males; leaves open relevance to clinical respiratory conditions.
Dyspnoea perception is influenced by a complex interplay of physiological, psychological, and environmental factors. Recently, we showed that males with high trait self-control experience less dyspnoea and persist for longer in a carbon dioxide (CO 2 ) rebreathing challenge than males with low trait self-control. As self-control can also vary within individuals (state self-control), the primary aim of the present study was to investigate whether prior self-control exertion influenced perceptions of dyspnoea and tolerance of a CO 2 rebreathing challenge in healthy young males. We also used functional near-infrared spectroscopy (fNIRS) to assess haemodynamic activity of the pre-frontal cortex (PFC) which is a region of interest (ROI) in dyspnoea research, and the primary brain region associated with exertion of self-control. In a within-subjects design, fifteen healthy young males completed an easy (congruent) Stroop task (control condition) and a difficult (incongruent) Stroop task (prior self-control exertion, experimental condition) followed by a CO 2 rebreathing challenge until the limit of tolerance. Changes in oxyhaemoglobin (ΔO 2 Hb) and deoxyhaemoglobin (ΔHHb) were assessed continuously in the Stroop task and CO 2 rebreathing challenge. During the CO 2 rebreathing challenge, dyspnoea intensity and unpleasantness were rated every 30 s. Prior self-control exertion did not affect perceptions of dyspnoea or tolerance time in the CO 2 rebreathing challenge (all P > 0.05). ΔO 2 Hb from baseline was higher in the left (+38 %) and right (+44 %) pre-frontal cortices during the difficult Stroop task than the easy Stroop task (both P < 0.05). During the subsequent CO 2 rebreathing challenge, ΔO 2 Hb was attenuated following prior self-control exertion in the left PFC. Although prior self-control exertion decreased pre-frontal cortex oxygenation during a subsequent CO 2 rebreathing challenge, there was no change in tolerance time or perceptions of dyspnoea. • Prior self-control exertion did not affect tolerance or perceptions of dyspnoea during a CO 2 rebreathing challenge. • During the self-control exertion task, PFC activity was higher than in the control task. • In the CO 2 rebreathing challenge, PFC activity was lower following the prior self-control exertion task.
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Brown et al. (2024) studied Healthy (n=15). Prior self-control exertion (difficult Stroop task) vs. Easy Stroop task (control condition) was evaluated on Perceptions of dyspnoea and tolerance time (p=>0.05). Prior self-control exertion decreased pre-frontal cortex oxygenation but did not affect perceptions of dyspnoea or tolerance time during a CO2 rebreathing challenge (P>0.05).
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