No Evidence for Tumorigenesis of AAV Vectors in a Large-Scale Study in Mice
Why the study?
Does administration of AAV vectors predispose mice to liver tumors?
Population
921 C57BL/6 mice (695 treated, 226 controls)
Comparison
Adeno-associated virus vectors, mostly via… vs Control mice (n=226)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports AAV safety in mice; leaves open human tumorigenicity assessment in gene therapy.
Structured PICO
Does administration of AAV vectors predispose mice to liver tumors?
P
Population
921 C57BL/6 mice (695 treated, 226 controls)
I
Intervention
Adeno-associated virus (AAV) vectors, mostly via portal vein injection
C
Comparator
Control mice (n=226)
O
Outcome
Formation of liver tumors at necropsysafety
AAV vectors do not appear to predispose mice to liver tumorigenesis, supporting their safety profile for gene therapy applications.
Cite This Study
Bell et al. (2005) studied this question.