Key result
Diastolic blood pressure variability was independently associated with higher orthostatic intolerance symptom scores (B = 0.46, p = 0.031).
Why the study?
Is blood pressure variability associated with the severity of orthostatic intolerance symptoms?
Cross-Sectional (n=103)
No
Is blood pressure variability associated with the severity of orthostatic intolerance symptoms?
Higher diastolic blood pressure variability is independently associated with more severe orthostatic intolerance symptoms.
Answers are grounded in this paper and cite their sources.
Suggests diastolic blood pressure variability may serve as a marker for orthostatic intolerance severity; leaves open whether.
The short-term blood pressure variability (BPV) reflects autonomic regulatory mechanisms. However, the influence of BPV in orthostatic intolerance (OI) is unknown. Herein, we assessed BPV profiles in patients with OI and determined their association with orthostatic symptoms. In this cross-sectional study, we prospectively enrolled 126 patients presenting with OI at the Seoul National University Hospital from December 2014 to August 2016. Among them, those with other neurological diseases (n = 8) and insufficient BP measurements (n = 15) were excluded. The degree of OI symptoms were measured using the self-administered orthostatic intolerance questionnaire (OIQ). All patients underwent ambulatory BP monitoring and we calculated the standard deviation and coefficient of variation as a measure of BPV. The mean age was 48.6 years and the average of the total OIQ score was 11.6. The severe OI group had higher BPV values than the mild group, although mean BP profiles did not differ significantly. Correlation analysis demonstrated that the orthostatic symptoms were positively correlated with diastolic BPV for the total and awake periods. Multiple linear regression analysis revealed that diastolic BPV (B = 0.46, p = 0.031) and current smoking (B = 4.687, p = 0.018) were independent factors for higher OI symptom scores after adjusting for covariates. The results of the current study demonstrated that a positive correlation exists between BPV and OI symptoms. Further studies are required to confirm the present findings and understand the neural mechanisms contributing to the excessive BPV in patients with OI.
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Sunwoo et al. (2017) conducted a cross-sectional in Orthostatic intolerance (n=103). Blood pressure variability was evaluated on Orthostatic intolerance symptom scores (OIQ) (B = 0.46, p=0.031). Diastolic blood pressure variability was independently associated with higher orthostatic intolerance symptom scores (B = 0.46, p = 0.031).
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