Key result
Children undergoing ventricular septal defect surgery with higher preoperative NT-proBNP levels had significantly longer hospitalization times (14.8 vs 13.1 days) compared to those with lower levels.
Why the study?
Limited evidence exists regarding whether NT-proBNP levels correlate with prognosis in pediatric patients undergoing ventricular septal defect repair.
Does a high NT-proBNP level predict worse short- and mid-term clinical outcomes in children undergoing ventricular septal defect surgery?
Cohort (n=798)
No
Does a high NT-proBNP level predict worse short- and mid-term clinical outcomes in children undergoing ventricular septal defect surgery?
Absolute Event Rate: 14.8% vs 13.1%
p-value: p=0.006
Higher preoperative NT-proBNP levels in children undergoing VSD surgery predict longer hospital stays and transiently lower ejection fraction at 1 month, whereas 24-hour postoperative NT-proBNP levels have no prognostic value.
May inform preoperative risk assessment in pediatric VSD surgery; hypothesis-generating and requires prospective validation before guiding care.
Background Limited study has shown whether NT-proBNP is related to the prognosis of children wth ventricular septal defect (VSD) surgery. The study was conducted to determine the predictive value of NT-proBNP on outcomes of children with VSD surgery. Methods A total of 798 children with VSD surgery were enrolled, with NT-proBNP measured at preoperatively and 24-h postoperatively. The short- and mid-term clinical outcomes were recorded. Propensity scores (PS) was performed to acquire pre-op and post NT-proBNP 24-h PS-matched cohorts for comparisons between groups. Results In the pre NT-proBNP PS-matched cohort, the higher NT pro-BNP group had longer hospitalization time and lower post-op 1-month EF value compared with low NT pro-BNP group (all P < 0.05), and there wasn't significant difference of mechanical ventilation time, cardiopulmonary bypass (CPB) time, intensive care unit (CCU) stay, and ejection fraction (EF) values of 3 month to 12 months after surgery (all P > 0.05). In the post NT-proBNP PS-matched cohort, there wasn't significant difference of mechanical ventilation time, CPB time, CCU stay, hospitalization time, and EF values of 1 month to 12 months after surgery between two groups (all P > 0.05). Conclusions VSD children with higher pre NT-proBNP level had longer hospital stays after surgery than those with lower level. Pre NT-proBNP level had no effect on mechanical ventilation time, CPB time, ACC time and CCU stay and cardiac function after 3 months postoperatively. Post-op 24-h NT pro-BNP level wasn't associated with clinical outcomes.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2025) conducted a cohort in Ventricular septal defect (n=798). High preoperative NT-proBNP level (≥75th percentile) vs. Low preoperative NT-proBNP level (<25th percentile) was evaluated on Hospitalization time (days) (p=0.006). Children undergoing ventricular septal defect surgery with higher preoperative NT-proBNP levels had significantly longer hospitalization times (14.8 vs 13.1 days) compared to those with lower levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: