The usefulness of brain natriuretic peptide in simple congenital heart disease – a systematic review
Why the study?
Does BNP/NT-proBNP measurement have diagnostic and prognostic value in patients with simple congenital heart disease?
Population
Patients with simple congenital heart disease, specifically atrial septal defect and ventricular septal defect
Comparison
Brain natriuretic peptide and N-terminal… vs Healthy age-matched controls
Design
Systematic_review
Authors
Discussion
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Member takes
Overview
Supports BNP as adjunct for assessing ASD/VSD severity; extends systematic evidence on biomarker correlations with hemodynamics.
Structured PICO
Does BNP/NT-proBNP measurement have diagnostic and prognostic value in patients with simple congenital heart disease?
P
Population
Patients with simple congenital heart disease, specifically atrial septal defect and ventricular septal defect
I
Intervention
Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) measurement
C
Comparator
Healthy age-matched controls
O
Outcome
Diagnostic and prognostic value of BNP/NT-proBNP (correlation with shunt severity, pulmonary artery pressure, and functional class)surrogate
BNP and NT-proBNP levels are mildly elevated in simple congenital heart disease and correlate with disease severity, suggesting utility as an additional tool in the diagnostic work-up.
Limitations
- Lack of large, prospective studies with long-term follow-up
Cite This Study
Eindhoven et al. (2012) studied this question.