Why the study?
Does infusion of ANP or BNP reduce mean pulmonary artery pressure and antagonize the pressor effects of angiotensin II in healthy volunteers?
Population
8 healthy volunteers
Comparison
Infusion of atrial natriuretic peptide or brain… vs Placebo infusion for 60 minutes, with…
Design
Other
Follow-up
60 minutes
Authors
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ANP/BNP may blunt angiotensin II pulmonary pressor effects in volunteers; leaves open translation to patients with pulmonary hypertension.
Does infusion of ANP or BNP reduce mean pulmonary artery pressure and antagonize the pressor effects of angiotensin II in healthy volunteers?
ANP and BNP exhibit pulmonary vasorelaxant activity in humans, effectively antagonizing the pulmonary pressor effects of angiotensin II.
Cargill et al. (1995) studied this question.
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