What question did this study set out to answer?

Determine whether serum paraoxonase 1 (PON1) lactonase activity is altered in end-stage renal disease and evaluate the immediate impact of hemodialysis.

October 20, 2010Clinical Chemistry and Laboratory Medicine (CCLM)

Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis

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Determine whether serum paraoxonase 1 (PON1) lactonase activity is altered in end-stage renal disease and evaluate the immediate impact of hemodialysis.
Evaluated 42 patients with end-stage renal disease undergoing hemodialysis and 49 healthy control subjects.
Measured PON1 lactonase, arylesterase, and triesterase activities using kinetic assays before and after hemodialysis sessions.
Serum lactonase activity was 11% lower in end-stage renal disease patients compared to healthy controls (p < 0.0001).
Lactonase activity significantly increased post-dialysis to levels comparable to healthy controls (repeated measures-ANOVA p < 0.0001, adjusted for age, sex, total cholesterol, triglycerides, and HDL cholesterol).
Changes in lactonase activity inversely correlated with dialysis-induced reductions in creatinine (r = -0.339, p = 0.028).

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Implication

Observational study reveals serum paraoxonase 1 lactonase activity is decreased in end-stage renal disease and restored by hemodialysis, indicating toxin-mediated enzyme suppression.

Cite This Study

Gugliucci et al. (2010) studied this question.

synapsesocial.com/papers/6a81d4cf28bb6950eb610504 https://doi.org/10.1515/cclm.2011.004

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Implication

Observational study reveals serum paraoxonase 1 lactonase activity is decreased in end-stage renal disease and restored by hemodialysis, indicating toxin-mediated enzyme suppression.

Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis

Key Points

Discussion

Implication

Cite This Study

Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis

Key Points

Discussion

Implication

Cite This Study

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