Key result
Antidepressant use in post-stroke patients is associated with potential adverse cardiovascular and cerebrovascular effects, including sudden cardiac death and stroke.
Antidepressants used for post-stroke depression may carry risks of adverse cardiovascular and cerebrovascular effects, including sudden cardiac death and stroke.
Answers are grounded in this paper and cite their sources.
May warrant caution with post-stroke antidepressants; leaves open causality and need for RCTs.
It is not unusual for patients to exhibit depressive symptoms after suffering a stroke. Although effective in managing depression, some antidepressants are believed to carry a risk of additional adverse cardiovascular and cerebrovascular effects, as well as the potential for drug‐drug interaction. Such adverse effects include conduction abnormalities and sudden death from the use of tricyclic antidepressant (TCA) drugs, and the possibility of sudden cardiac death associated with selective serotonin reuptake inhibitors (SSRIs). 1 , 2 In addition, there are conflicting data in the literature regarding the association between antidepressant use and stroke. Although the exact mechanism is unknown, thicker arteries related to antidepressant use have been suggested as a plausible explanation. 3
No takes yet. Share an insight, caveat, or question.
Y. W. Francis Lam (2016) conducted a review in Depressive symptoms after stroke. Antidepressants was evaluated. Antidepressant use in post-stroke patients is associated with potential adverse cardiovascular and cerebrovascular effects, including sudden cardiac death and stroke.
Synapse has enriched 10 related papers. Consider them for comparative context: