Heat-stability study of various insulin types in tropical temperature conditions: New insights towards improving diabetes care

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– According to pharmacopeia, unopened insulin vials must be stored in a refrigerator (2–8 °C) while storage at ambient temperature (25–28 °C) is usually permitted for the 4-week usage period during treatment– The authors investigated whether insulin remains stable and retains biological activity in oscillating tropical temperatures– They found that the structure of insulin and its efficiency on insulin receptor and Akt phosphorylation in hepatic cells remain stable at temperatures oscillating between 25 and 37 °C over a 4-week period, which enables the barrier of cold storage to be removed