What question did this study set out to answer?

Determine the primary chemical structure and biological activity of the cardioexcitatory neuropeptide peak C isolated from ganglia of the clam Macrocallista nimbosa.

August 12, 1977Science

Structure of a Molluscan Cardioexcitatory Neuropeptide

View Full Paper

Ask AI

Bookmark

Determine the primary chemical structure and biological activity of the cardioexcitatory neuropeptide peak C isolated from ganglia of the clam Macrocallista nimbosa.
Determined the peptide sequence using Edman dansyl degradation combined with tryptic digestion.
Synthesized the identified sequence chemically and assayed its biological activity on molluscan muscle tissue.
Identified the peak C cardioexcitatory substance as the tetrapeptide amide Phe-Met-Arg-Phe-NH2.
Demonstrated that the neuropeptide is biologically active on molluscan muscle at a concentration of approximately 10⁻⁸ M.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Biochemical analysis reveals the tetrapeptide structure of a cardioexcitatory neuropeptide in clam ganglia, highlighting potent muscular activity at nanomolar concentrations.

Cite This Study

Price et al. (1977) studied this question.

synapsesocial.com/papers/6a81db516494b7aed7bf7625 https://doi.org/10.1126/science.877582

View Full Paper

Ask AI

Bookmark

Implication

Biochemical analysis reveals the tetrapeptide structure of a cardioexcitatory neuropeptide in clam ganglia, highlighting potent muscular activity at nanomolar concentrations.

Structure of a Molluscan Cardioexcitatory Neuropeptide

Key Points

Discussion

Implication

Cite This Study

Structure of a Molluscan Cardioexcitatory Neuropeptide

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider