Highlights the potential medical and legal risks of severe extrapyramidal side effects when prescribing phenothiazine derivatives to pediatric patients.
Joshi et al, authors of "Neuroleptic Malignant Syndrome: Life-threatening Complication of Neuroleptic Treatment in Adolescents with Affective Disorder," were correct in emphasizing the potential danger of neuroleptics in children with any disorder. It appears that the extrapyramidal side effects of phenothiazine derivatives, including drugs such as prochlorperazine maleate (Compazine), may be more frequent and more severe in pediatric patients. The purpose of this letter is to alert physicians to the potential medical/legal consequences of treating children with phenothiazine derivatives.
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Michael S. B. Edwards (1991) studied this question.
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