Key result
Metoclopramide linked to suspected neuroleptic malignant and serotonin syndrome overlap in a 19-month-old child.
Case Report (n=1)
This first pediatric report highlights the potential for metoclopramide to trigger an overlap of neuroleptic malignant syndrome and serotonin syndrome.
Suggests caution with metoclopramide in young children; leaves open the prevalence of NMS-serotonin syndrome overlap.
A 19-month-old child presented with fever and acute neurological deterioration with hypertonia, tremors, and clonus 1 day after starting metoclopramide. The clinical course of the patient was suggestive of neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS), which can both be triggered by metoclopramide. This first pediatric report of an overlap between NMS and SS associated to metoclopramide highlights the importance of considering this new entity and its consequences on treatment.
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Aussedat et al. (2020) conducted a case report in Suspected overlap between serotonin syndrome and neuroleptic malignant syndrome (n=1). Metoclopramide was evaluated on Development of neuroleptic malignant syndrome and serotonin syndrome. Metoclopramide treatment in a 19-month-old child triggered an acute neurological deterioration suggestive of an overlap between neuroleptic malignant syndrome and serotonin syndrome.
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