Why the study?
Does metoclopramide induce neuroleptic malignant-like syndrome?
Does metoclopramide induce neuroleptic malignant-like syndrome?
Metoclopramide can cause a life-threatening neuroleptic malignant-like syndrome, necessitating dose adjustment in patients with renal failure.
Raises awareness for metoclopramide-associated neuroleptic malignant-like syndrome; single case leaves open incidence and risk factors.
A prompt recognition of neuroleptic malignant-like syndrome is essential because of its high morbidity and mortality. A similar condition i described associated with metoclopramide, an agent with dopamine receptor-blocking properties. An increased index of suspicion for early diagnosis of this condition and adjustment of metoclopramide dosing in patients with renal failure are emphasized.
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M. Reza Samie (1987) studied this question.
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