Metoclopramide, a commonly used anti-emetic, can rarely cause life-threatening Neuroleptic Malignant Syndrome requiring prompt recognition and treatment.
Metoclopramide warrants NMS vigilance in antiemetic use; case reports leave open incidence and risk-factor quantification.
Neuroleptic Malignant Syndrome (NMS) is a medical emergency. It presents with mental status change, rigidity, fever, and autonomic dysfunction. It is caused by antipsychotics especially neuroleptic agents and certain antiemetic drugs like metoclopramide that block central dopamine pathways. We present a case of a 32year-old male chronic alcoholic who presented to us with alcohol withdrawal symptoms and was given injection metoclopramide and developed neuroleptic malignant syndrome (NMS).
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Acharya et al. (2020) studied this question.
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