Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice

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Population

Wild-type (WT) or transgenic LQT3 mice (Scn5a(+/ΔKPQ))

Comparison

Light phase-restricted feeding paradigm vs Normal light and feeding cues

Design

Preclinical

Authors

Discussion

Time-restricted feeding aggravates LQT3 phenotype in mice; leaves open whether meal timing modulates repolarization or arrhythmia risk in patients.

Population

Wild-type (WT) or transgenic LQT3 mice (Scn5a(+/ΔKPQ))

Intervention

Light phase-restricted feeding paradigm

Comparator

Normal light and feeding cues

Outcome

Heart rate (RR interval) and ventricular repolarization (QT and QTc intervals)surrogate

Uncoupling feeding time from normal light cues slows heart rate and aggravates the LQT3-related phenotype in a mouse model.

Schroder et al. (2014) studied this question.

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Time-restricted feeding aggravates LQT3 phenotype in mice; leaves open whether meal timing modulates repolarization or arrhythmia risk in patients.