The unexpected becomes possible: The first enantioselective, direct nucleophilic substitution of Morita–Baylis–Hillman alcohols has been developed through the use of iminium catalysis. Unexpected δ-substituted products were obtained with exclusive regioselectivity and high enantioselectivity for the reaction of cyclopent-2-enone-derived alcohols with indoles catalyzed by 1.
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Qiao et al. (2010) studied this question.
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