Why the study?
Acute gastroenteritis causes a significant global burden, and the authors aimed to determine the predominant enteric viral pathogens detected post-rotavirus vaccine introduction in county Mayo.
Rotavirus remained the predominant cause of gastroenteritis in children under 3 years old in the first year post-rotavirus vaccination in this Irish region.
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Rotavirus predominance persists post-vaccination in this cohort; leaves open questions on vaccine impact and need for prospective surveillance.
Acute gastroenteritis harbours a significant global burden. Rotavirus is the primary cause of gastroenteritis in children worldwide. We aim to determine the predominant enteric viral pathogens detected in the post-rotavirus vaccine period (2016-2017) in our region in county Mayo (west of Ireland), United Kingdom. All children up to 3 years old, who presented to Mayo University Hospital with vomiting and diarrhoea, from November 18th, 2016, to November 18th, 2017, had their stools tested by real-time reverse transcription polymerase chain reaction for viral pathogens. A total of 150 stool samples were tested, and 90 (60%) tested positive for a single viral pathogen. Rotavirus was the leading cause of gastroenteritis (37 patients, 24.6%; including 6 rotavirus vaccinated infants), followed by human adenovirus F (19 patients, 13%), norovirus (18 patients, 12%), sapovirus (9 patients, 6%) and astrovirus (7 patients, 5%). Rotavirus remained the predominant cause of gastroenteritis in the first year post-rotavirus vaccination, similar to the national Irish data from the pre vaccination years (July 2014-June 2015).
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Zakaria Barsoum (2021) studied this question.
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