European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease

In the article that appeared on page 136 of the January 2012 issue, a number of errors are noted, as follows: Page 138, paragraph 4, the sentence should read: When duodenal biopsies, taken during routine diagnostic workup for gastrointestinal symptoms, disclose a histological pattern indicative of CD (Marsh 1–3 lesions), antibody determinations and HLA typing should be performed. Page 139, last paragraph, the sentence should read: In 2008, the UK National Institute for Health and Clinical Evidence (NICE) published guidelines for the diagnosis and management of CD in general practice (78a). Page 140, under “Symptoms and Signs,” the sentence should read: Gastrointestinal symptoms frequently appear in clinically diagnosed childhood CD, including diarrhoea in about 50% of patients (15,16). Page 144, Table 3, the second sentence in the footnote should read: Data also from Richtlijn Coeliakie en Dermatitis Herpetiformis. Kwaliteitsinstituut voor de Gesondheidszorg CBO (33a). Page 144, line 10, the sentence should read:The sensitivity of HLA-DQ2 is high (median 91%; p25 – p7586.3%– 94.0%), and if combined with HLA-DQ8 (at least 1 is positive), it is even higher (median 96.2%; p25 – p75 94.6%–99.8%), making extremely small the chance of an individual who is negative for DQ2 and DQ8 to have CD; even though the small percentage of HLA-DQ2-negative and HLA-DQ8-negative patients is well documented (33–35). Page 144, Table 4, the second sentence in the footnote should read: Data also from Richtlijn Coeliakie en Dermatitis Herpetiformis. Kwaliteitsinstituut voor de Gesondheidszorg CBO (33a). Page 146, paragraph 6, the penultimate line should read: Anti-TG2 antibodies also can be detected in saliva. Sufficient sensitivity and specificity was not achieved with conventional commercially available immunoassays (63), although the use of radiobinding assays appeared to be more favourable (64). Page 146, paragraph 8, the first sentence should read: The positivity for anti-TG2 and/or EMA is associated with a high probability for CD in children and adolescents (10,52); however, low levels of anti-TG2 have been described in a number of conditions unrelated to CD, such as other autoimmune diseases, infections, tumours, myocardial damage, liver disorders, and psoriasis (62,68 – 70). Page 147, statement 3.3.5, the second sentence should read: For other tests, values considered to be high antibody positivity should be established by comparison with a panel of tests, which are listed in Appendix I. Page 147, statement 3.3.8, the first sentence should read: High concentrations of anti-TG2 antibodies in blood (as defined in statement 3.3.5) predict villous atrophy better than low positive or borderline values. Page 149, statement 3.4.10, the voting results should read: Total number of votes: 13, Agree: 12, Disagree: 1, Abstentions: 0 Page 159, reference 78a should read: National Institute for Health and Clinical Excellence. CG86 coeliac disease: full guideline. NICE guidelines. http://guidance.nice.org.uk/CG86/NICEGuidance/pdf/English. Accessed August 31, 2011. Figures 1 and 2 are replaced as follows:FIGURE 1: Symptomatic patient. CD = coeliac disease; EMA = endomysial antibodies; F/u = follow-up; GFD = gluten-free diet; HLA = human leukocyte antigen; IgA = immunoglobulin A; IgG = immunoglobulin G; OEGD = oesophagogastroduodenoscopy; TG2 = transglutaminase type 2.FIGURE 2: Asymptomatic patient. See Fig. 1 for definitions.