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March 24, 2023Open Access

Protective Effects of Thymoquinone on Doxorubicin-induced Anti/oxidant Levels in Rat Peripheral Tissues

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Why the study?

The study aimed to investigate the protective effects of thymoquinone against doxorubicin-induced toxicity across multiple rat peripheral tissues.

Does thymoquinone prevent doxorubicin-induced oxidative stress and lipid peroxidation in peripheral tissues of rats?

Population

Twenty-eight healthy male Wistar albino rats aged three months

Comparison

Control vs thymoquinone vs doxorubicin vs doxorubicin plus thymoquinone

Design

Four-group animal experimental study

Authors

DADeniz AkpınarMuğla UniversityTMTanju MercanAkdeniz UniversityHDHalit DemirVan Yüzüncü Yıl Üniversitesi

Discussion

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Implication

Thymoquinone attenuated doxorubicin oxidative stress in rat tissues; leaves open whether it protects human peripheral organs.

Structured PICO

Does thymoquinone prevent doxorubicin-induced oxidative stress and lipid peroxidation in peripheral tissues of rats?

P
Population
28 healthy male Wistar albino rats aged three months, weighing 300 to 350 g
I
Intervention
Thymoquinone 10 mg/kg given by gavage at 24-hour intervals for 4 weeks, combined with doxorubicin 3 mg/kg injected intraperitoneally 5 times every other day (15 mg/kg total)
C
Comparator
Doxorubicin alone (3 mg/kg IP 5 times every other day), thymoquinone alone (10 mg/kg by gavage daily), and control (saline IP and vehicle by gavage)
O
Outcome
Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) in lung, liver, stomach, kidney, diaphragm, and testicular tissues at 4 weekssurrogate

Thymoquinone mitigates doxorubicin-induced oxidative stress and lipid peroxidation in multiple peripheral tissues in a rat model.

Cite This Study

Akpınar et al. (2023) studied this question.

synapsesocial.com/papers/6a81e891ebcdd2e0baf1ff0fhttps://doi.org/10.21203/rs.3.rs-2702180/v1
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