Population
Chicken gizzard filamin and heavy merofilamin (proteins isolated from smooth muscle)
Design
Preclinical
Authors
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Filamin dimerization enables actin cross-linking in vitro; leaves open whether proteolytic fragments regulate cytoskeletal function in cardiovascular cells.
Filamin produces gelation of F-actin by binding to actin and self-associating to cross-link actin filaments, a property lost in its proteolytic fragment heavy merofilamin.
Davies et al. (1980) studied this question.
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