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Regulating the expression of target genes in response to different conditions is one of the most daunting tasks facing the cell. In a Perspective, [Struhl][1] describes the intricate steps involved in assembly of a precise transcriptional on-off switch called the enhanceosome, which regulates the transcription of the interferon-b gene in response to viral infection ([ Munshi et al .][2]). [1]: http://www.sciencemag.org/cgi/content/full/293/5532/1054 [2]: http://www.sciencemag.org/cgi/content/short/293/5532/1133
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Kevin Struhl (2001) studied this question.
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