Why the study?
Calciphylaxis rarely occurs in the absence of renal disease, where it may be associated with various comorbidities or medication triggers such as warfarin.
This case report highlights warfarin as a potential trigger for nonuremic calciphylaxis, particularly in patients with underlying thrombophilia such as Factor V Leiden deficiency.
May prompt alternative anticoagulation consideration in Factor V Leiden; leaves open causal confirmation for nonuremic calciphylaxis.
Calciphylaxis is a rare condition of cutaneous ischemia resulting from calcium deposition into dermal and subcutaneous blood vessels, followed by thrombosis. It most often occurs in the setting of end-stage renal disease (uremic calciphylaxis) but can also occur in the absence of renal disease (nonuremic calciphylaxis) and may be associated with a variety of comorbidities or medication triggers. This article details a case of nonuremic, warfarin-associated calciphylaxis in a 64-year-old female with Factor V Leiden deficiency and provides a review of calciphylaxis clinical presentation, pathophysiology, risk factors, diagnosis, mimickers, and management.
No takes yet. Share an insight, caveat, or question.
A 2025 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: