What question did this study set out to answer?

To determine how sequential exposure to antigenic variants of influenza virus shapes age-specific and population-wide antibody profiles over time.

December 1, 1953The Journal of Experimental MedicineOpen Access

Epidemiologic and Immunologic Significance of Age Distribution of Antibody to Antigenic Variants of Influenza Virus

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Authors

FDFred M. DavenportRockefeller Foundation AHAlbert V. HennessyUniversity of Michigan TFThomas FrancisCentre National de la Recherche Scientifique

Discussion

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Implication

Cross-sectional serologic analysis demonstrates age-dependent antibody patterns in human sera, indicating that childhood influenza infections imprint lifelong humoral immunity.

Key Points

To determine how sequential exposure to antigenic variants of influenza virus shapes age-specific and population-wide antibody profiles over time.
Measured strain-specific antibody titers against diverse Type A, Type B, and swine influenza viruses in serial lots of gamma globulin prepared between 1943 and 1951.
Profiled antibody distributions across age-stratified human serum pools collected within a single year.
Antibodies to A-prime strains were elevated in infants and children but largely undetectable after age 20, whereas swine influenza antibodies were detected only in individuals aged 29 years and older.
Antibody spectra were narrow in early childhood and broadened progressively with increasing age, with older cohorts maintaining persistent baseline antibody titers to earlier strains.
Peak antibody levels within each age cohort corresponded to the specific influenza strains that circulated during that cohort's initial childhood exposures.

Cite This Study

Davenport et al. (1953) studied this question.

synapsesocial.com/papers/6a81f22d265c63e88772b5bc https://doi.org/10.1084/jem.98.6.641

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Implication

Cross-sectional serologic analysis demonstrates age-dependent antibody patterns in human sera, indicating that childhood influenza infections imprint lifelong humoral immunity.

Epidemiologic and Immunologic Significance of Age Distribution of Antibody to Antigenic Variants of Influenza Virus

Discussion

Member takes

Implication

Key Points

Cite This Study

Epidemiologic and Immunologic Significance of Age Distribution of Antibody to Antigenic Variants of Influenza Virus

Discussion

Member takes

Implication

Key Points

Cite This Study

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