Experimental study demonstrates ruthenium-catalyzed ortho-C–H hydroxyfluoroalkylation of arenes using fluorinated alcohols and TEMPO, highlighting a practical route to fluorinated building blocks.
-C-H hydroxyfluoroalkylation of arenes with cheap and easily accessible fluorinated alcohols has been developed in the presence of 2,2,6,6-tetramethyl-1-piperidinyloxyl (TEMPO). The readily available fluorinated alcohols were used as hydroxyfluoroalkylation reagents to form various α-aryl-α-trifluoromethyl alcohols. The present work provides a new method for the introduction of hydroxyfluoroalkyl groups into arenes.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: