Why the study?
Does neuronal nitric oxide synthase inhibition alter systemic and renal hemodynamics differently in diabetic versus control rats?
Does neuronal nitric oxide synthase inhibition alter systemic and renal hemodynamics differently in diabetic versus control rats?
Neuronal nitric oxide synthase-derived nitric oxide regulates systemic and renal hemodynamics, with increased activity in the diabetic kidney that is modulated by angiotensin II.
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Suggests heightened nNOS dependence in diabetic rat kidneys; leaves open whether angiotensin II modulation translates to human diabetic nephropathy.
Komers et al. (2000) studied this question.
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