Why the study?
Is there intra-individual concordance in blood pressure response between an ARB (candesartan) and an ACE-I (lisinopril) in patients with essential hypertension?
Is there intra-individual concordance in blood pressure response between an ARB (candesartan) and an ACE-I (lisinopril) in patients with essential hypertension?
Individual blood pressure responses to ACE inhibitors and ARBs are poorly correlated, suggesting that lack of efficacy with one class does not preclude a response to the other.
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Nonresponse to one agent does not predict nonresponse to the other; challenges interchangeability assumptions and supports sequential trials in hypertension.
Sever et al. (2001) studied this question.
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