April 1, 2025JRSM Cardiovascular Disease

Multiple intra-cavitary thrombi in a late-onset dilated cardiomyopathy with severely reduced ejection fraction: A case report and review of the literature

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Why the study?

Dilated cardiomyopathy may rarely be complicated by left ventricular thrombi, which carry a significant risk of systemic embolization.

Structured PICO

Population

77-year-old woman with dyslipidemia, depression, progressive dyspnea (NYHA IV), severe biventricular dysfunction (LVEF 24%), and multiple partially mobile left ventricular thrombi, with a heterozygous BAG3 variant.

Intervention

Unfractionated heparin followed by apixaban, plus guideline-directed medical therapy for heart failure (bisoprolol, sacubitril-valsartan, dapagliflozin, spironolactone).

Outcome

Resolution of left ventricular thrombi and improvement in left ventricular ejection fractionsurrogate

Prompt anticoagulation and guideline-directed medical therapy can lead to complete resolution of left ventricular thrombi and favorable remodeling in patients with dilated cardiomyopathy and BAG3 mutation.

Discussion

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Implication

Supports anticoagulation and GDMT in BAG3 cardiomyopathy with thrombi; hypothesis-generating for genetic DCM.

Cite This Study

Iorgi et al. (2025) studied this question.

synapsesocial.com/papers/6a81fe8f2f94e177df06def7 https://doi.org/10.1177/20480040251395237

View Full Paper

Ask AI

Bookmark

Multiple intra-cavitary thrombi in a late-onset dilated cardiomyopathy with severely reduced ejection fraction: A case report and review of the literature

Structured PICO

Discussion

Implication

Cite This Study

Multiple intra-cavitary thrombi in a late-onset dilated cardiomyopathy with severely reduced ejection fraction: A case report and review of the literature

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider