Why the study?
Does long-term inhalation of nitric oxide improve symptoms and oxygenation in a pediatric patient with primary pulmonary hypertension?
Does long-term inhalation of nitric oxide improve symptoms and oxygenation in a pediatric patient with primary pulmonary hypertension?
Long-term inhaled nitric oxide may safely improve dyspnea and oxygenation in pediatric primary pulmonary hypertension, though withdrawal at higher doses can cause rebound pulmonary hypertension.
May support low-dose inhaled NO for symptom relief in pediatric primary PH; leaves open long-term efficacy and optimal protocols.
Primary pulmonary hypertension is a disease with a high mortality rate and for which there is no satisfactory medical treatment. The safety of long-term inhalation of nitric oxide (NO) as a treatment is described. A 9-year-old girl inhaled NO for 32 weeks, accompanied with oral administration of beraprost sodium. Although NO did not improve her long-term prognosis, it eased the patient's dyspnea and increased her blood oxygenation. At doses of 20 ppm or more, attempts to withdraw from inhaled NO seemed to lead to an immediate elevation of the pulmonary artery pressure. This rebound phenomenon did not happen at doses under 5 ppm. This case study suggests that long-term inhalation of NO is safe and effective, but that pulmonary hypertension may rebound following withdrawal at higher doses of NO.
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Koh et al. (1998) studied this question.
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