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May 27, 2021Frontiers in PhysiologyOpen Access

Effects of (Pro)renin Receptor on Diabetic Cardiomyopathy Pathological Processes in Rats via the PRR-AMPK-YAP Pathway

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Why the study?

The mechanisms responsible for the effects of the (pro)renin receptor and YAP on diabetic cardiomyopathy remained unclear.

Population

Diabetic cardiomyopathy rat model and primary rat cardiac fibroblasts

Comparison

PRR and YAP modulation with or without GSK621

Design

Preclinical animal and in vitro study

Authors

JXJie XiongRuijin HospitalXDXuefei DongChinese Academy of Medical Sciences & Peking Union Medical CollegeSLShengnan LiZhengzhou Normal University

Discussion

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Implication

Hypothesis-generating for PRR-YAP inhibition in diabetic cardiomyopathy; requires clinical validation before any practice change.

Structured PICO

P
Population
120 male 8-week-old Wistar rats (200 ± 12 g) with streptozotocin (STZ)-induced diabetic cardiomyopathy, and primary rat neonatal cardiac fibroblasts cultured in high glucose.
I
Intervention
Recombinant adenoviruses expressing PRR shRNA (Ad-PRR-shRNA), YAP (Ad-YAP), or lentivirus expressing YAP shRNA (LV-YAP-shRNA) administered via tail vein. In vitro: GSK621 (AMPK agonist, 30 µM).
C
Comparator
Control rats, untreated diabetic cardiomyopathy (DCM) rats, and DCM rats treated with scramble shRNA (Ad-SC-shRNA or LV-SC-shRNA) or empty vector (Ad-EGFP).
O
Outcome
Myocardial inflammation and fibrosis levels (protein expression of Collagen I, Fibronectin, PAI-1, TGF-β, IL-1β, IL-18) and cardiac function (LVEF, LVESD, LVEDD, E/A ratio).surrogate

Inhibition of the (pro)renin receptor (PRR) or YAP alleviates myocardial inflammation and fibrosis in diabetic cardiomyopathy via the PRR-AMPK-YAP pathway, offering a potential novel therapeutic target.

Cite This Study

Xiong et al. (2021) studied this question.

synapsesocial.com/papers/6a81ffa0cb8186709ca204c4https://doi.org/10.3389/fphys.2021.657378
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetic Cardiomyopathy Revisited2007 · 1,553 citations
  2. 2The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy2011 · 41 citations
  3. 3(Pro)renin Receptor Is an Amplifier of Wnt/β-Catenin Signaling in Kidney Injury and Fibrosis2017 · 123 citations
  4. 4Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin2002 · 1,281 citations
  5. 5Traumatic occlusion aggravates bone loss during periodontitis and activates Hippo‐YAP pathway2019 · 36 citations