March 21, 2008EndocrinologyOpen Access

Central Role of Gqin the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Cultured vascular smooth muscle cells (VSMCs)

Intervention

Pharmacological G(q) inhibitor or adenovirus encoding a G(q) inhibitory minigene

Comparator

No G(q) inhibition (AngII stimulation alone) or G protein-independent AT(1) agonist

Outcome

Intracellular Ca(2+) elevation, EGFR transactivation, ROCK substrate phosphorylation, and hypertrophic responses (cellular protein and cell volume)surrogate

G(q) plays a major role in the EGFR pathway leading to AngII-induced vascular hypertrophy, highlighting it as a potential therapeutic target.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

G(q) inhibition merits further preclinical study in vascular hypertrophy; leaves open any clinical translation.

Cite This Study

Ohtsu et al. (2008) studied this question.

synapsesocial.com/papers/6a82020528bb6950eb611376 https://doi.org/10.1210/en.2007-1694

View Full Paper

Ask AI

Bookmark

Central Role of Gqin the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells

Structured PICO

Discussion

Implication

Cite This Study

Central Role of Gqin the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider