What question did this study set out to answer?

To review literature evaluating the acute and long-term haemodynamic responses to ten different beta-adrenoceptor antagonists and explore the role of intrinsic sympathomimetic activity in their antihypertensive actions.

April 1, 1982British Journal of Clinical PharmacologyOpen Access

How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta‐adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism.

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Why the study?

How does intrinsic sympathomimetic activity modulate the acute and long-term haemodynamic responses to different beta-adrenoceptor antagonists?

Population

806 patients from a literature survey

Design

Review

Authors

MVMan in't AJ VeldErasmus MC MSMA SchalekampErasmus MC

Discussion

Member takes

Implication

ISA may guide beta-blocker selection by haemodynamic profile; leaves open prospective outcome trials.

Key Points

To review literature evaluating the acute and long-term haemodynamic responses to ten different beta-adrenoceptor antagonists and explore the role of intrinsic sympathomimetic activity in their antihypertensive actions.
Reviewed literature assessing acute and long-term haemodynamic effects of ten beta-blockers: pindolol, practolol, alprenolol, oxprenolol, acebutolol, penbutolol, metoprolol, atenolol, propranolol, and timolol.
Evaluated data from 396 patients across 41 acute studies and 410 patients across 36 long-term studies.
Demonstrated that the presence and degree of intrinsic sympathomimetic activity modulate circulatory and haemodynamic responses across different beta-adrenoceptor antagonists.
Identified critical qualitative differences in acute versus long-term cardiovascular effects among the ten evaluated pharmacological agents.

Structured PICO

How does intrinsic sympathomimetic activity modulate the acute and long-term haemodynamic responses to different beta-adrenoceptor antagonists?

Population

806 patients (396 patients in 41 acute studies and 410 patients in 36 long-term studies) from a literature survey

Intervention

Ten different beta-1-adrenoceptor antagonists (pindolol, practolol, alprenolol, oxprenolol, acebutolol, penbutolol, metoprolol, atenolol, propranolol, and timolol)

Outcome

Acute and long-term haemodynamic effectssurrogate

This literature survey evaluates the acute and long-term haemodynamic effects of ten beta-blockers to understand how intrinsic sympathomimetic activity modulates their antihypertensive mechanisms.

Cite This Study

Veld et al. (1982) studied this question.

synapsesocial.com/papers/6a820942f453150ffdd82b7d https://doi.org/10.1111/j.1365-2125.1982.tb01922.x

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How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta‐adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta‐adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider