The Diagnostic Value of Serum TgAb in the Tg-Negative and TgAb-Positive DTC Patients after Successful Ablation

341 patients with histologically confirmed differentiated thyroid carcinoma (DTC) who had undergone total or subtotal thyroidectomy followed by radioiodine remnant ablation and showed thyroglobulin (Tg)-negative and TgAb-positive (Tg-TgAb+) status. Divided into recurrence group (n=119) and no evidence of disease (NED) group (n=222).

Serum thyroglobulin antibody (TgAb) level measurement

Clinical routine diagnostic methods (gold standard: biopsy and/or routine clinical examinations including chest x-rays, CT scanning, neck high-resolution echography, and radioiodine whole body scan)

Diagnostic accuracy of serum TgAb for recurrence (Area under the ROC curve, sensitivity, specificity, and cut-off value)surrogate