Why the study?
Patients may experience ischaemic stroke despite DOAC therapy, creating uncertainty regarding whether they can safely receive intravenous thrombolysis or mechanical thrombectomy.
Can patients with acute ischaemic stroke on DOAC therapy safely receive intravenous thrombolysis or mechanical thrombectomy?
Can patients with acute ischaemic stroke on DOAC therapy safely receive intravenous thrombolysis or mechanical thrombectomy?
This review highlights that mechanical thrombectomy is safe for acute ischemic stroke patients on DOACs, while IV thrombolysis requires a precision medicine approach using coagulation assays or reversal agents.
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Supports MT without selection criteria in DOAC-treated stroke; leaves open optimal IVT protocols pending prospective trials.
Seiffge et al. (2021) studied this question.
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