Population
In vitro and in vivo models for studying human LINE-1 (L1Hs) translation
Comparison
Insertion of a stable hairpin structure at nt… vs Unmodified L1Hs element (implied)
Design
Preclinical
Authors
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Hypothesis-generating for L1 retrotransposon control; leaves open relevance to human cardiovascular models.
The findings suggest that L1Hs ORF1 translation initiation involves ribosome scanning, whereas ORF2 translation is likely initiated internally rather than by reinitiation.
McMillan et al. (1993) studied this question.
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