November 17, 2015European Heart JournalOpen Access

Correlates of pre-hospital morphine use in ST-elevation myocardial infarction patients and its association with in-hospital outcomes and long-term mortality: the FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) programme

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Why the study?

Does pre-hospital morphine use worsen in-hospital complications and 1-year survival in STEMI patients?

Population

4,164 ST-elevation MI patients from the French Registry of Acute ST-elevation and non-ST-elevation…

Comparison

Pre-hospital morphine use vs No pre-hospital morphine use

Design

Cohort

Follow-up

1 year

Authors

ÉPÉtienne PuymiratInterventional / Structural Cardiology LLLionel LamhautHôpital Necker-Enfants Malades NBNicolas BonnetNestlé (Switzerland)

Discussion

Member takes

Implication

Does not support avoiding pre-hospital morphine in STEMI over survival concerns; leaves open need for randomized confirmation.

Structured PICO

Does pre-hospital morphine use worsen in-hospital complications and 1-year survival in STEMI patients?

Population

4,164 ST-elevation MI (STEMI) patients from the French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction (FAST-MI) (2,438 from the 2010 cohort and 1,726 from the 2005 cohort)

Intervention

Pre-hospital morphine use

Comparator

No pre-hospital morphine use

Outcome

In-hospital complications (death, non-fatal re-MI, stroke, stent thrombosis, and bleeding) and 1-year survivalhard clinical

Pre-hospital morphine use in STEMI patients does not appear to worsen in-hospital complications or 1-year mortality, despite theoretical concerns regarding delayed antiplatelet absorption.

Cite This Study

Puymirat et al. (2015) studied this question.

synapsesocial.com/papers/6a821653ae3e8f2bede2283c https://doi.org/10.1093/eurheartj/ehv567

Topics

STEMI management Dual antiplatelet therapy

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Correlates of pre-hospital morphine use in ST-elevation myocardial infarction patients and its association with in-hospital outcomes and long-term mortality: the FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) programme

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Correlates of pre-hospital morphine use in ST-elevation myocardial infarction patients and its association with in-hospital outcomes and long-term mortality: the FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) programme

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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