Why the study?
Activated charcoal based compounds remove DOAC interference in vitro, but few studies have used this approach with global coagulation assays.
Does DOAC-stop allow accurate analysis of global coagulation assays by removing DOAC interference without significantly altering baseline coagulation parameters?
Population
DOAC-spiked pooled normal plasma and platelet poor plasma from 21 non-anticoagulated adults
Comparison
Before vs after DOAC-stop addition
Design
In vitro laboratory study
Authors
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Supports DS for animal coagulation studies; leaves open human validation before clinical global assay use.
Does DOAC-stop allow accurate analysis of global coagulation assays by removing DOAC interference without significantly altering baseline coagulation parameters?
DOAC-stop causes minor changes to global coagulation assay parameters but maintains strong pre- and post-treatment correlations, supporting its use to evaluate underlying thrombotic states in anticoagulated patients.
Wang et al. (2023) studied this question.
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