Why the study?
Foot-and-mouth disease virus is a major livestock pathogen constraining global trade, and validation of the primary and persistent sites of infection under natural contact exposure was needed.
Population
Vaccinated and nonvaccinated cattle
Comparison
Vaccinated vs nonvaccinated cattle exposed to FMDV
Design
Standardized pig-to-cow contact exposure model study
Authors
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Highlights nasopharyngeal mucosa as FMDV intervention target in cattle; hypothesis-generating pending translational studies.
The study validates the bovine nasopharyngeal mucosa as the primary and persistent site of FMDV infection, highlighting it as a target for future vaccines and biotherapeutics.
Stenfeldt et al. (2018) studied this question.
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